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台灣本土疫情日益嚴峻，其中新北2歲幼童染疫出現重症更讓家長們憂心不已，且兒童究竟該施打哪種廠牌的疫苗、會有哪些副作用？也引發各界激辯。其實，世界3大新冠疫苗之一的莫德納疫苗，上月就公布其兒童實驗結果，總計6,900多名兒童接種後產生相對明顯的免疫反應，但「6個月至6歲幼童」並未有心肌炎的案例。
綜合外媒報導，該實驗的劑量為2劑各25微克，僅為18歲以上劑量的4分之1，測驗結果顯示，兒童接種會產生類似成年人的抗體反應，副作用程度皆為輕度或中度，且所有受測兒童都未出現心肌炎症狀。歐盟、澳洲等30個國家，過去對6到11歲兒童施打疫苗的結果則顯示，最常見副作用為注射部位疼痛、頭痛、疲倦和發燒，類似成年人會出現的副作用。
不過，在現有疫苗對Omicron保護力相對較低的情況下，6個月到2歲兒童的保護力為43.7％，2至6歲僅有37.5％。「生醫所研究員」何美鄉也指出，美國紐約州對36萬名兒童施打2劑BNT疫苗後，其「效益」在3周後僅剩下平均12％，顯示疫苗劑量可能影響接種者的防護力。不過多國醫師和專家都強調，兒童注射疫苗的重點在於降低住院或重症風險，而不是期望它能阻止感染，即使疫苗保護力相對較高、注射2劑或加強劑的大人，仍會遭到突破性感染。
疫苗緊急使用授權（EUA）會議召集人鍾飲文指出，莫德納疫苗曾在兒童臨床試驗分為全劑量、半劑量及4分之1劑量等多種組合，但考量免疫反應和安全性，全劑量免疫反應雖強，但擔憂不良反應過大，因此選擇半劑量進行後續試驗，來證實保護力及安全性。台大兒童醫院院長黃立民也表示，從臨床來看，兒童副作用沒有比較多，且多以急性過敏為主，因此兒童如有嚴重過敏，接種後應觀察30分鐘，確定無礙後再離開。
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